Technology 出版物・特許

蛋白質間相互作用の制御を可能にするPepMetics技術

MEDCHEM NEWS, 35(2), 75-80 (2025) Hajime Takashima, Research and Development Department, PRISM BioLab Co., Ltd.

https://www.jstage.jst.go.jp/article/medchem/35/2/35_75/_article/-char/ja

Rational Strategy for Designing Peptidomimetic Small Molecules Based on Cyclic Peptides Targeting Protein–Protein Interaction between CTLA-4 and B7-1

Pharmaceuticals 2022, 15(12), 1506
Tsuihiji, Kumiko; Honda, Eiji; Kojoh, Kanehisa; Katoh, Shizue; Taguri, Tomonori; Yoshimori, Atsushi; Takashima, Hajime

Development of low-molecular-weight compounds targeting the cancer-associated KLF5 transcription factor

ACS Medicinal Chemistry Letters, 13(4), 687-694 (2022)
Nakaya, Takeo; Aizawa, Kenichi; Taguchi, Yuki; Tsuji, Kentaro; Sekine, Sachi; Murakami, Kazuhiro; Kasai, Masaji; Nakano, Hirofumi; Kondoh, Yasumitsu; Dan, Shingo; Yoshimori, Atsushi; Kouji, Hiroyuki; Takehara, Dai; Suzuki, Toru; Osada, Hiroyuki; Marata, Masayuki; Tanaka, Akira; Nagai, Ryozo

Visualized and Quantitative Conformational Analysis of Peptidomimetics

ACS omega, 6(40), 26601-26612 (2021)
Takashima, Hajime; Yoshimori, Atsushi; Honda, Eiji; Taguri, Tomonori; Ozawa, Jun; Kasai, Masaji; Shuto, Satoshi; Takehara, Dai

Generalized-ensemble method study: A helix-mimetic compound inhibits protein-protein interaction by long-range and short-range intermolecular interactions

Journal of Computational Chemistry, 42(14), 956-969 (2021)
Higo, Junichi; Takashima, Hajime; Fukunishi, Yoshifumi; Yoshimori, Atsushi

E7386, a selective inhibitor of the interaction between β-catenin and CBP, exerts antitumor activity in tumor models with activated canonical wnt signaling

Cancer Research, 81(4), 1052-1062 (2021)
Yamada, Kazuhiko; Hori, Yusaku; Inoue, Satoshi; Yamamoto, Yuji; Iso, Kentaro; Kamiyama, Hiroshi; Yamaguchi, Atsumi; Kimura, Takayuki; Uesugi, Mai; Ito, Junichi; Matsuki, Masahiro; Nakamoto, Kazutaka; Harada, Hitoshi; Yoneda, Naoki; Takemura, Atsushi; Kushida, Ikuo; Wakayama, Naomi; Kubara, Kenji; Kato, Yu; Semba, Taro; Yokoi, Akira; Matsukura, Masayuki; Odagami, Takenao; Iwata, Masao; Tsuruoka, Akihiko; Uenaka, Toshimitsu; Matsui, Junji; Matsushima, Tomohiro; Nomoto, Kenichi; Kouji, Hiroyuki; Owa, Takashi; Funahashi, Yasuhiro; Ozawa, Yoichi

Anti-tumor activity of the small molecule inhibitor PRI-724 against β-catenin-activated hepatocellular carcinoma

Anticancer Research, 40, 5211-5219 (2020)
Gabata, Ryosuke; Harada, Kenichi; Mizutani, Yuki; Ouchi, Hirofumi; Yoshimura, Kaori; Sato, Yasunori; Kitao, Azusa; Kimura, Kiminori; Kouji, Hiroyuki; Miyashita, Tomoharu; Tajima, Hidehiro; Ohta, Tetsuo

β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis

Scientific Reports, 9(1), 20056 (2019)
Hirakawa, Tomoko; Nasu, Kaei; Miyabe, Saori; Kouji, Hiroyuki; Katoh, Akira; Uemura, Naoto; Narahara, Hisashi

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model

Pharmacology Biochemistry and Behavior, 176, 1-5 (2019)
Kawase, Haruki; Ago, Yukio; Naito, Megumi; Higuchi, Momoko; Hara, Yuta; Hasebe, Shigeru; Tsukada, Shinji; Kasai, Atsushi; Nakazawa, Takanobu; Mishina, Tadashi; Kouji, Hiroyuki; Takuma, Kazuhiro; Hashimoto, Hitoshi

The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice

Experimental Lung Research, 45(7), 188-199 (2019)
Okazaki, Hiroyasu; Sato, Seidai; Koyama, Kazuya; Morizumi, Shun; Abe, Shuichi; Azuma, Momoyo; Chen, Yajuan; Goto, Hisatsugu; Aono, Yoshinori; Ogawa, Hirohisa; Kagawa, Kozo; Nishimura, Haruka; Kawano, Hiroshi; Toyoda, Yuko; Uehara, Hisanori; Kouji, Hiroyuki; Nishioka, Yasuhiko

A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models

Bioorganic and Medicinal Chemistry Letters, 27, 4705-4709 (2017)
Ueda, Hiroshi; Jun-ichi Kurita; Neyama, Hiroyuki; Hirao, Yuuka; Kouji, Hiroyuki; Mishina, Tadashi; Kasai, Masaji; Nakano, Hirofumi; Yoshimori, Atsushi; Nishimura, Yoshifumi

Establishment of an intermittent cold stress model using Tupaia Belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor

Experimental Animals, 65(3), 285-292 (2016)
Hai-Ying, Chi; Nagano, Kiori; Ezzikouri, Sayeh; Yamaguchi, Chiho; Kayesh, Mohammad Enamul Hoque; Rebbani, Khadija; Kitab, Bouchra; Nakano, Hirohumi; Kouji, Hiroyuki; Kohara, Michinori; Tsukiyama-Kohara, Kyoko

Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity

F1000Research, 4, 75 (2015)
Gupta-Ostermann, Disha; Hirose, Yoichiro; Odagami, Takenao; Kouji, Hiroyuki; Bajorath, Jurgen

Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain

Organic Letters, 15(7), 1686-1689 (2013)
Mizuno, Akira; Miura, Shiho; Watanabe, Mizuki; Ito, Yoshihiko; Yamada, Shizuo; Odagami, Takenao; Kogami, Yuji; Arisawa, Mitsuhiro; Shuto, Satoshi

Protein-Protein Interaction をターゲットとした創薬

Medchem News, 22(1), 21-24 (2012) (Japanese)
Odagami, Takenao; Kouji, Hiroyuki

Deprotection of Nin-formyl group on tryptophan by application of new reagent, 1,2-dimethylethylendiamine in aqueous solution

Advances in Experimental Medicine and Biology, 611, 159-160 (2009)
Odagami, Takenao; Kogami, Yuji; Kouji, Hiroyuki; Tsuda, Yuko; Okada, Yoshio

Identification of new agonists of urotensin-II from a cyclic peptide library

Bioorganic and Medicinal Chemistry, 17, 6742-6747 (2009)
Odagami, Takenao; Tsuda, Yuko; Kogami, Yuji; Kouji, Hiroyuki; Okada, Yoshio

Deprotection of the indole (Nind)-formyl (For) group on tryptophan employing a new reagent, N,N’-dimethylethylendiamine (DMEDA) in an aqueous solution

Chemical and Pharmaceutical Bulletin, 57(2), 211-213 (2009)
Odagami, Takenao; Tsuda, Yuk; Kogami, Yuji; Kouji, Hiroyuki; Okada, Yoshio