In Drug Discovery, there are many successful examples developing enzyme inhibitors and receptor agonists/antagonists. However, attempts to develop modulators of Protein/Protein Interaction have largely been a failure. This is especially true in developing modulators for transcription factors. Thus, modulation of Intracellular Protein/Protein Interaction by small molecules is difficult at best.

Helix structures are prevalent and are often observed in Intracellular Protein/Protein Interaction. PRISM Library was designed based on Helix structures and has exhibited the strong activity for modulating critical Intracellular Protein/Protein Interaction.

Screening the "PRISM Library" has resulted in the discovery of compounds that can selectively control various Intracellular Protein/Protein Interactions (especially, Interaction between transcription factors).